The falsification of medicines is a worldwide scourge, but one that particularly affects developing countries, causing a great deal of damage, including deaths. Fake medicines are seized by customs every year. However, very few studies have looked at the qualitative and quantitative analysis of medicines found in Africa, both in pharmacies and on the markets. This study aims to analyze several drugs purchased in Togo in the cities of Kara and Lomé to ensure that they actually have the active ingredients indicated inside, which is one of the guarantees of their quality. The samples were analyzed by HPLC coupled with MS/MS which is a method of choice for the identification of molecules of interest. Analysis of the spectra obtained showed that the samples purchased on the markets (analgesics, anti-inflammatory drugs and antibiotics) contain all the active ingredients indicated on the package. This result is reassuring because 100% of the samples analyzed are of good quality. However, it will be necessary to make additional studies by adding other classes of drugs such as anti-malarials that are most affected by falsification on the African continent. A quantitative study should also be done to determine the amount of each active ingredient in the tablets studied. It will be interesting to study the excipients contained in drugs because, although they are not active principles, they have an influence on the metabolism of active molecules.
| Published in | Science Journal of Chemistry (Volume 12, Issue 1) |
| DOI | 10.11648/sjc.20241201.12 |
| Page(s) | 15-22 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Drugs, LC-MS/MS, Kara, Lomé
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APA Style
Marie-France, B. (2024). Analysis by LC-Ms/Ms of Drugs Sold in the Markets of Kara and Lome. Science Journal of Chemistry, 12(1), 15-22. https://doi.org/10.11648/sjc.20241201.12
ACS Style
Marie-France, B. Analysis by LC-Ms/Ms of Drugs Sold in the Markets of Kara and Lome. Sci. J. Chem. 2024, 12(1), 15-22. doi: 10.11648/sjc.20241201.12
AMA Style
Marie-France B. Analysis by LC-Ms/Ms of Drugs Sold in the Markets of Kara and Lome. Sci J Chem. 2024;12(1):15-22. doi: 10.11648/sjc.20241201.12
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Download@article{10.11648/sjc.20241201.12,
author = {Bakaï Marie-France},
title = {Analysis by LC-Ms/Ms of Drugs Sold in the Markets of Kara and Lome},
journal = {Science Journal of Chemistry},
volume = {12},
number = {1},
pages = {15-22},
doi = {10.11648/sjc.20241201.12},
url = {https://doi.org/10.11648/sjc.20241201.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.sjc.20241201.12},
abstract = {The falsification of medicines is a worldwide scourge, but one that particularly affects developing countries, causing a great deal of damage, including deaths. Fake medicines are seized by customs every year. However, very few studies have looked at the qualitative and quantitative analysis of medicines found in Africa, both in pharmacies and on the markets. This study aims to analyze several drugs purchased in Togo in the cities of Kara and Lomé to ensure that they actually have the active ingredients indicated inside, which is one of the guarantees of their quality. The samples were analyzed by HPLC coupled with MS/MS which is a method of choice for the identification of molecules of interest. Analysis of the spectra obtained showed that the samples purchased on the markets (analgesics, anti-inflammatory drugs and antibiotics) contain all the active ingredients indicated on the package. This result is reassuring because 100% of the samples analyzed are of good quality. However, it will be necessary to make additional studies by adding other classes of drugs such as anti-malarials that are most affected by falsification on the African continent. A quantitative study should also be done to determine the amount of each active ingredient in the tablets studied. It will be interesting to study the excipients contained in drugs because, although they are not active principles, they have an influence on the metabolism of active molecules.
},
year = {2024}
}
TY - JOUR T1 - Analysis by LC-Ms/Ms of Drugs Sold in the Markets of Kara and Lome AU - Bakaï Marie-France Y1 - 2024/02/01 PY - 2024 N1 - https://doi.org/10.11648/sjc.20241201.12 DO - 10.11648/sjc.20241201.12 T2 - Science Journal of Chemistry JF - Science Journal of Chemistry JO - Science Journal of Chemistry SP - 15 EP - 22 PB - Science Publishing Group SN - 2330-099X UR - https://doi.org/10.11648/sjc.20241201.12 AB - The falsification of medicines is a worldwide scourge, but one that particularly affects developing countries, causing a great deal of damage, including deaths. Fake medicines are seized by customs every year. However, very few studies have looked at the qualitative and quantitative analysis of medicines found in Africa, both in pharmacies and on the markets. This study aims to analyze several drugs purchased in Togo in the cities of Kara and Lomé to ensure that they actually have the active ingredients indicated inside, which is one of the guarantees of their quality. The samples were analyzed by HPLC coupled with MS/MS which is a method of choice for the identification of molecules of interest. Analysis of the spectra obtained showed that the samples purchased on the markets (analgesics, anti-inflammatory drugs and antibiotics) contain all the active ingredients indicated on the package. This result is reassuring because 100% of the samples analyzed are of good quality. However, it will be necessary to make additional studies by adding other classes of drugs such as anti-malarials that are most affected by falsification on the African continent. A quantitative study should also be done to determine the amount of each active ingredient in the tablets studied. It will be interesting to study the excipients contained in drugs because, although they are not active principles, they have an influence on the metabolism of active molecules. VL - 12 IS - 1 ER -
Laboratory of Organic Chemistry and Environmental Sciences (LaCOSE), Department of Chemistry, Faculty of Science and Technology, Kara University, Kara, Togo
