Hepatitis B Prevalence and Risk Factors in Chronic Liver Disease Patients at Hawassa University Comprehensive Specialized Hospital, Sidama Region, Ethiopia

Bezaye Lemma Deregasso; Robel Habtamu Ababiya; Rediet Ajebu Nurfeta; Tsion Habtamu Ababiya; Lijalem Abera Tema; Bemnet Gossaye Teka; Selamawit Seifu Hailu; Dereje Kebede Shane

doi:doi:10.11648/j.sjcm.20241301.11

Research Article |

Hepatitis B Prevalence and Risk Factors in Chronic Liver Disease Patients at Hawassa University Comprehensive Specialized Hospital, Sidama Region, Ethiopia

Bezaye Lemma Deregasso, Robel Habtamu Ababiya^*, Rediet Ajebu Nurfeta, Tsion Habtamu Ababiya, Lijalem Abera Tema, Bemnet Gossaye Teka, Selamawit Seifu Hailu, Dereje Kebede Shane

Published in Science Journal of Clinical Medicine (Volume 13, Issue 1)

Received: 22 November 2023 Accepted: 22 December 2023 Published: 8 January 2024

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Abstract

Background: Chronic liver disease (CLD) is a progressive deterioration of liver functions for more than six months, which includes the synthesis of clotting factors, and other proteins, detoxification of harmful products of metabolism, and excretion of bile. Viral hepatitis is one of the main causes of CLD. Objective: The main objective of this study is to determine the prevalence and associated risk factors of hepatitis B infection among patients visiting the medical referral clinic at Hawassa University Comprehensive Specialized Hospital, Sidama region, Ethiopia. Methods: A cross-sectional study was conducted on patients attending a medical referral clinic at Hawassa University Comprehensive Specialized Hospital, Sidama region, Ethiopia during the study period from October 2019 to August 2021 by reviewing the medical cards of 329 patients. The collected data was analyzed by data software and outcomes are presented by tables, figures, and statements. Result: A total of 195 adult patients with a sign and symptoms of CLD were included in this study. Of these 143 (73.3%) male and 52 (26.7%) female participated in the study. The mean age of the participant was 33.5 years (SD ±12) most of the patients were in the 26-35 age range. The majority 57% of the study participants were rural residents. Considering marital status 66.7% of the study participants were married. The most common cause of chronic liver disease is caused by chronic HBV (79.5%) followed by Hepatosplenic Schistosomiasis (5.6%) with positive HBsAg 0% and 3% respectively. Among 195 chronic liver disease patients, 143 (73.3%) were male and 21 (62.1%) were positive for HBsAg which were statistically significant with (COR 2.9 and 95% CI 1.4-6.). Of those who were Child-Pugh Class A (113) were positive for HBsAg 103 (52.8) (COR, 5.5; 95% CI, 2.2–14; P-Value 0.0001) and compensated patient where (COR, 8; 95% CI, 3.5–19; P-Value 0.0001) for which both are statically significant. Risk factors associated with HBV among chronic liver disease the following were significantly associated with hospital admission (COR, 53.4; 95% CI, 1.5–8; P-Value 0.002) and blood transfusion (COR, 0.22; 95% CI, 0.1–0.5; P-Value 0.0001). Conclusions: The present study has shown that HBV (79.5%) was highly prevalent among patients with chronic liver disease. Screening all possible close contacts (relatives) of patients with HBV and giving immunization to this group and if possible giving public immunization of HBV is recommended to halt HBV infection. Most patients in this study group are compensated 57.4% and Child Class A 59.5% which gives time to implement treatment to decrease disease progression to the worsen. and this study will give insight into availing appropriate medication for treatment

Published in	Science Journal of Clinical Medicine (Volume 13, Issue 1)
DOI	10.11648/j.sjcm.20241301.11
Page(s)	1-8
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Hepatitis B, Chronic Liver Disease, Viral Hepatitis, Hawassa University Comprehensive Specialized Hospital, Liver Failure

References

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[3]	Ministry of Health - Ethiopia. (2016). National Guideline for Prevention and Control of Viral Hepatitis in Ethiopia.
[4]	Terrault, N. A., Lok, A. S. F., McMahon, B. J., Chang, K., Hwang, J. P., & Jonas, M. M. (2018). Update on Prevention, Diagnosis, and Treatment of Chronic Hepatitis B: AASLD 2018 Hepatitis B Guidance. Hepatology, 67(4), 1560–1599.
[5]	Janssen, H. L. A., & Sleisenger, S. F. (2021). Sleisenger and Fordtran’s Gastrointestinal and Liver Disease (11th ed.).
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[8]	Asrani, S. K., Devarbhavi, H., Eaton, J., & Kamath, P. S. (2019). The burden of liver diseases in the world. Journal of Hepatology, 70(1), 151–171.
[9]	Chang, M.-H. (2011). Clinical Cancer Prevention (Chapter 6 Hepatitis B Virus and Cancer Prevention).
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[11]	Farrell, G., Lee, C., Yuen, H., Tanwandee, T., Tao, Q., Shue, K., et al. (2004). Lamivudine for Patients with Chronic Hepatitis B and Advanced Liver Disease, 1521–1531.
[12]	Papatheodoridis, G. V., Lampertico, P., Manolakopoulos, S., & Lok, A. (2010). Review Incidence of hepatocellular carcinoma in chronic hepatitis B patients receiving nucleos (t) ide therapy: A systematic review. Journal of Hepatology, 53(2), 348–356.
[13]	Amsalu, A., Ferede, G., Eshetie, S., Tadewos, A., & Assegu, D. (2018). Prevalence, Infectivity, and Associated Risk Factors of Hepatitis B Virus among Pregnant Women in Yirgalem Hospital, Ethiopia: Implication of Screening to Control Mother-to-Child Transmission. Journal of Pregnancy, 2018.
[14]	Taye, S., Abdulkerim, A., & Hussein, M. (2014). Prevalence of hepatitis B and C virus infections among patients with chronic hepatitis at Bereka Medical Center, Southeast Ethiopia: A retrospective study. BMC Research Notes, 7(1), 1–4.
[15]	Taye, M., Daka, D., Amsalu, A., & Hussen, S. (2019). The magnitude of hepatitis B and C virus infections and associated factors among patients scheduled for surgery at Hawassa University Comprehensive Specialized Hospital, Hawassa City, southern Ethiopia. BMC Research Notes, 12(1), 1–6.
[16]	Saravanan, S., Velu, V., Kumarasamy, N., Muthu, E., Nandakumar, S., Murugavel, K. G., et al. (2008). The prevalence of hepatitis B virus and hepatitis C virus infection among patients with chronic liver disease in South India.
[17]	Ayele, A., Abera, D., Hailu, M., Birhanu, M., & Desta, K. (2020). Prevalence and associated risk factors for Hepatitis B and C viruses among refugees in Gambella, Ethiopia. BMC Public Health, 20(1), 1–10.
[18]	Editor, D. (2004). Prevalence of Hepatitis C and B Viral Markers in Patients with Chronic Liver Disease: A Study from Northern India.
[19]	Tong, C. Y. W., Khan, R., Beeching, N. J., Tariq, W. U. Z., & Hart, C. A. (2021). The occurrence of hepatitis B and C viruses in Pakistani patients with chronic liver disease and hepatocellular carcinoma.

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Deregasso, B. L., Ababiya, R. H., Nurfeta, R. A., Ababiya, T. H., Tema, L. A., et al. (2024). Hepatitis B Prevalence and Risk Factors in Chronic Liver Disease Patients at Hawassa University Comprehensive Specialized Hospital, Sidama Region, Ethiopia. Science Journal of Clinical Medicine, 13(1), 1-8. https://doi.org/10.11648/j.sjcm.20241301.11

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Deregasso, B. L.; Ababiya, R. H.; Nurfeta, R. A.; Ababiya, T. H.; Tema, L. A., et al. Hepatitis B Prevalence and Risk Factors in Chronic Liver Disease Patients at Hawassa University Comprehensive Specialized Hospital, Sidama Region, Ethiopia. Sci. J. Clin. Med. 2024, 13(1), 1-8. doi: 10.11648/j.sjcm.20241301.11

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AMA Style

Deregasso BL, Ababiya RH, Nurfeta RA, Ababiya TH, Tema LA, et al. Hepatitis B Prevalence and Risk Factors in Chronic Liver Disease Patients at Hawassa University Comprehensive Specialized Hospital, Sidama Region, Ethiopia. Sci J Clin Med. 2024;13(1):1-8. doi: 10.11648/j.sjcm.20241301.11

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@article{10.11648/j.sjcm.20241301.11,
  author = {Bezaye Lemma Deregasso and Robel Habtamu Ababiya and Rediet Ajebu Nurfeta and Tsion Habtamu Ababiya and Lijalem Abera Tema and Bemnet Gossaye Teka and Selamawit Seifu Hailu and Dereje Kebede Shane},
  title = {Hepatitis B Prevalence and Risk Factors in Chronic Liver Disease Patients at Hawassa University Comprehensive Specialized Hospital, Sidama Region, Ethiopia},
  journal = {Science Journal of Clinical Medicine},
  volume = {13},
  number = {1},
  pages = {1-8},
  doi = {10.11648/j.sjcm.20241301.11},
  url = {https://doi.org/10.11648/j.sjcm.20241301.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20241301.11},
  abstract = {Background: Chronic liver disease (CLD) is a progressive deterioration of liver functions for more than six months, which includes the synthesis of clotting factors, and other proteins, detoxification of harmful products of metabolism, and excretion of bile. Viral hepatitis is one of the main causes of CLD. Objective: The main objective of this study is to determine the prevalence and associated risk factors of hepatitis B infection among patients visiting the medical referral clinic at Hawassa University Comprehensive Specialized Hospital, Sidama region, Ethiopia. Methods: A cross-sectional study was conducted on patients attending a medical referral clinic at Hawassa University Comprehensive Specialized Hospital, Sidama region, Ethiopia during the study period from October 2019 to August 2021 by reviewing the medical cards of 329 patients. The collected data was analyzed by data software and outcomes are presented by tables, figures, and statements. Result: A total of 195 adult patients with a sign and symptoms of CLD were included in this study. Of these 143 (73.3%) male and 52 (26.7%) female participated in the study. The mean age of the participant was 33.5 years (SD ±12) most of the patients were in the 26-35 age range. The majority 57% of the study participants were rural residents. Considering marital status 66.7% of the study participants were married. The most common cause of chronic liver disease is caused by chronic HBV (79.5%) followed by Hepatosplenic Schistosomiasis (5.6%) with positive HBsAg 0% and 3% respectively. Among 195 chronic liver disease patients, 143 (73.3%) were male and 21 (62.1%) were positive for HBsAg which were statistically significant with (COR 2.9 and 95% CI 1.4-6.). Of those who were Child-Pugh Class A (113) were positive for HBsAg 103 (52.8) (COR, 5.5; 95% CI, 2.2–14; P-Value 0.0001) and compensated patient where (COR, 8; 95% CI, 3.5–19; P-Value 0.0001) for which both are statically significant. Risk factors associated with HBV among chronic liver disease the following were significantly associated with hospital admission (COR, 53.4; 95% CI, 1.5–8; P-Value 0.002) and blood transfusion (COR, 0.22; 95% CI, 0.1–0.5; P-Value 0.0001). Conclusions: The present study has shown that HBV (79.5%) was highly prevalent among patients with chronic liver disease. Screening all possible close contacts (relatives) of patients with HBV and giving immunization to this group and if possible giving public immunization of HBV is recommended to halt HBV infection. Most patients in this study group are compensated 57.4% and Child Class A 59.5% which gives time to implement treatment to decrease disease progression to the worsen. and this study will give insight into availing appropriate medication for treatment
},
 year = {2024}
}

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TY  - JOUR
T1  - Hepatitis B Prevalence and Risk Factors in Chronic Liver Disease Patients at Hawassa University Comprehensive Specialized Hospital, Sidama Region, Ethiopia
AU  - Bezaye Lemma Deregasso
AU  - Robel Habtamu Ababiya
AU  - Rediet Ajebu Nurfeta
AU  - Tsion Habtamu Ababiya
AU  - Lijalem Abera Tema
AU  - Bemnet Gossaye Teka
AU  - Selamawit Seifu Hailu
AU  - Dereje Kebede Shane
Y1  - 2024/01/08
PY  - 2024
N1  - https://doi.org/10.11648/j.sjcm.20241301.11
DO  - 10.11648/j.sjcm.20241301.11
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 1
EP  - 8
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20241301.11
AB  - Background: Chronic liver disease (CLD) is a progressive deterioration of liver functions for more than six months, which includes the synthesis of clotting factors, and other proteins, detoxification of harmful products of metabolism, and excretion of bile. Viral hepatitis is one of the main causes of CLD. Objective: The main objective of this study is to determine the prevalence and associated risk factors of hepatitis B infection among patients visiting the medical referral clinic at Hawassa University Comprehensive Specialized Hospital, Sidama region, Ethiopia. Methods: A cross-sectional study was conducted on patients attending a medical referral clinic at Hawassa University Comprehensive Specialized Hospital, Sidama region, Ethiopia during the study period from October 2019 to August 2021 by reviewing the medical cards of 329 patients. The collected data was analyzed by data software and outcomes are presented by tables, figures, and statements. Result: A total of 195 adult patients with a sign and symptoms of CLD were included in this study. Of these 143 (73.3%) male and 52 (26.7%) female participated in the study. The mean age of the participant was 33.5 years (SD ±12) most of the patients were in the 26-35 age range. The majority 57% of the study participants were rural residents. Considering marital status 66.7% of the study participants were married. The most common cause of chronic liver disease is caused by chronic HBV (79.5%) followed by Hepatosplenic Schistosomiasis (5.6%) with positive HBsAg 0% and 3% respectively. Among 195 chronic liver disease patients, 143 (73.3%) were male and 21 (62.1%) were positive for HBsAg which were statistically significant with (COR 2.9 and 95% CI 1.4-6.). Of those who were Child-Pugh Class A (113) were positive for HBsAg 103 (52.8) (COR, 5.5; 95% CI, 2.2–14; P-Value 0.0001) and compensated patient where (COR, 8; 95% CI, 3.5–19; P-Value 0.0001) for which both are statically significant. Risk factors associated with HBV among chronic liver disease the following were significantly associated with hospital admission (COR, 53.4; 95% CI, 1.5–8; P-Value 0.002) and blood transfusion (COR, 0.22; 95% CI, 0.1–0.5; P-Value 0.0001). Conclusions: The present study has shown that HBV (79.5%) was highly prevalent among patients with chronic liver disease. Screening all possible close contacts (relatives) of patients with HBV and giving immunization to this group and if possible giving public immunization of HBV is recommended to halt HBV infection. Most patients in this study group are compensated 57.4% and Child Class A 59.5% which gives time to implement treatment to decrease disease progression to the worsen. and this study will give insight into availing appropriate medication for treatment

VL  - 13
IS  - 1
ER  -

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Author Information

Bezaye Lemma Deregasso

Department of Internal Medicine, Hawassa University Referral Hospital, Hawassa, Ethiopia

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Robel Habtamu Ababiya

Department of Internal Medicine, Wolaita Sodo University Comprehensive Specialized Hospital, Wolaita Sodo, Ethiopia

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Rediet Ajebu Nurfeta

Department of Internal Medicine, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia

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Tsion Habtamu Ababiya

Department of Internal Medicine, Wolaita Sodo University Comprehensive Specialized Hospital, Wolaita Sodo, Ethiopia

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Lijalem Abera Tema

Department of Internal Medicine, Wolaita Sodo University Comprehensive Specialized Hospital, Wolaita Sodo, Ethiopia

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Bemnet Gossaye Teka

Lesua Ethiopia, Addis Ababa, Ethiopia

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Selamawit Seifu Hailu

Department of Internal Medicine, Wolaita Sodo University Comprehensive Specialized Hospital, Wolaita Sodo, Ethiopia

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Dereje Kebede Shane

Department of Internal Medicine, Wachemo University, Hadiya Hosanna, Ethiopia

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APA Style

Deregasso, B. L., Ababiya, R. H., Nurfeta, R. A., Ababiya, T. H., Tema, L. A., et al. (2024). Hepatitis B Prevalence and Risk Factors in Chronic Liver Disease Patients at Hawassa University Comprehensive Specialized Hospital, Sidama Region, Ethiopia. Science Journal of Clinical Medicine, 13(1), 1-8. https://doi.org/10.11648/j.sjcm.20241301.11

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ACS Style

Deregasso, B. L.; Ababiya, R. H.; Nurfeta, R. A.; Ababiya, T. H.; Tema, L. A., et al. Hepatitis B Prevalence and Risk Factors in Chronic Liver Disease Patients at Hawassa University Comprehensive Specialized Hospital, Sidama Region, Ethiopia. Sci. J. Clin. Med. 2024, 13(1), 1-8. doi: 10.11648/j.sjcm.20241301.11

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AMA Style

Deregasso BL, Ababiya RH, Nurfeta RA, Ababiya TH, Tema LA, et al. Hepatitis B Prevalence and Risk Factors in Chronic Liver Disease Patients at Hawassa University Comprehensive Specialized Hospital, Sidama Region, Ethiopia. Sci J Clin Med. 2024;13(1):1-8. doi: 10.11648/j.sjcm.20241301.11

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@article{10.11648/j.sjcm.20241301.11,
  author = {Bezaye Lemma Deregasso and Robel Habtamu Ababiya and Rediet Ajebu Nurfeta and Tsion Habtamu Ababiya and Lijalem Abera Tema and Bemnet Gossaye Teka and Selamawit Seifu Hailu and Dereje Kebede Shane},
  title = {Hepatitis B Prevalence and Risk Factors in Chronic Liver Disease Patients at Hawassa University Comprehensive Specialized Hospital, Sidama Region, Ethiopia},
  journal = {Science Journal of Clinical Medicine},
  volume = {13},
  number = {1},
  pages = {1-8},
  doi = {10.11648/j.sjcm.20241301.11},
  url = {https://doi.org/10.11648/j.sjcm.20241301.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjcm.20241301.11},
  abstract = {Background: Chronic liver disease (CLD) is a progressive deterioration of liver functions for more than six months, which includes the synthesis of clotting factors, and other proteins, detoxification of harmful products of metabolism, and excretion of bile. Viral hepatitis is one of the main causes of CLD. Objective: The main objective of this study is to determine the prevalence and associated risk factors of hepatitis B infection among patients visiting the medical referral clinic at Hawassa University Comprehensive Specialized Hospital, Sidama region, Ethiopia. Methods: A cross-sectional study was conducted on patients attending a medical referral clinic at Hawassa University Comprehensive Specialized Hospital, Sidama region, Ethiopia during the study period from October 2019 to August 2021 by reviewing the medical cards of 329 patients. The collected data was analyzed by data software and outcomes are presented by tables, figures, and statements. Result: A total of 195 adult patients with a sign and symptoms of CLD were included in this study. Of these 143 (73.3%) male and 52 (26.7%) female participated in the study. The mean age of the participant was 33.5 years (SD ±12) most of the patients were in the 26-35 age range. The majority 57% of the study participants were rural residents. Considering marital status 66.7% of the study participants were married. The most common cause of chronic liver disease is caused by chronic HBV (79.5%) followed by Hepatosplenic Schistosomiasis (5.6%) with positive HBsAg 0% and 3% respectively. Among 195 chronic liver disease patients, 143 (73.3%) were male and 21 (62.1%) were positive for HBsAg which were statistically significant with (COR 2.9 and 95% CI 1.4-6.). Of those who were Child-Pugh Class A (113) were positive for HBsAg 103 (52.8) (COR, 5.5; 95% CI, 2.2–14; P-Value 0.0001) and compensated patient where (COR, 8; 95% CI, 3.5–19; P-Value 0.0001) for which both are statically significant. Risk factors associated with HBV among chronic liver disease the following were significantly associated with hospital admission (COR, 53.4; 95% CI, 1.5–8; P-Value 0.002) and blood transfusion (COR, 0.22; 95% CI, 0.1–0.5; P-Value 0.0001). Conclusions: The present study has shown that HBV (79.5%) was highly prevalent among patients with chronic liver disease. Screening all possible close contacts (relatives) of patients with HBV and giving immunization to this group and if possible giving public immunization of HBV is recommended to halt HBV infection. Most patients in this study group are compensated 57.4% and Child Class A 59.5% which gives time to implement treatment to decrease disease progression to the worsen. and this study will give insight into availing appropriate medication for treatment
},
 year = {2024}
}

Copy | Download

TY  - JOUR
T1  - Hepatitis B Prevalence and Risk Factors in Chronic Liver Disease Patients at Hawassa University Comprehensive Specialized Hospital, Sidama Region, Ethiopia
AU  - Bezaye Lemma Deregasso
AU  - Robel Habtamu Ababiya
AU  - Rediet Ajebu Nurfeta
AU  - Tsion Habtamu Ababiya
AU  - Lijalem Abera Tema
AU  - Bemnet Gossaye Teka
AU  - Selamawit Seifu Hailu
AU  - Dereje Kebede Shane
Y1  - 2024/01/08
PY  - 2024
N1  - https://doi.org/10.11648/j.sjcm.20241301.11
DO  - 10.11648/j.sjcm.20241301.11
T2  - Science Journal of Clinical Medicine
JF  - Science Journal of Clinical Medicine
JO  - Science Journal of Clinical Medicine
SP  - 1
EP  - 8
PB  - Science Publishing Group
SN  - 2327-2732
UR  - https://doi.org/10.11648/j.sjcm.20241301.11
AB  - Background: Chronic liver disease (CLD) is a progressive deterioration of liver functions for more than six months, which includes the synthesis of clotting factors, and other proteins, detoxification of harmful products of metabolism, and excretion of bile. Viral hepatitis is one of the main causes of CLD. Objective: The main objective of this study is to determine the prevalence and associated risk factors of hepatitis B infection among patients visiting the medical referral clinic at Hawassa University Comprehensive Specialized Hospital, Sidama region, Ethiopia. Methods: A cross-sectional study was conducted on patients attending a medical referral clinic at Hawassa University Comprehensive Specialized Hospital, Sidama region, Ethiopia during the study period from October 2019 to August 2021 by reviewing the medical cards of 329 patients. The collected data was analyzed by data software and outcomes are presented by tables, figures, and statements. Result: A total of 195 adult patients with a sign and symptoms of CLD were included in this study. Of these 143 (73.3%) male and 52 (26.7%) female participated in the study. The mean age of the participant was 33.5 years (SD ±12) most of the patients were in the 26-35 age range. The majority 57% of the study participants were rural residents. Considering marital status 66.7% of the study participants were married. The most common cause of chronic liver disease is caused by chronic HBV (79.5%) followed by Hepatosplenic Schistosomiasis (5.6%) with positive HBsAg 0% and 3% respectively. Among 195 chronic liver disease patients, 143 (73.3%) were male and 21 (62.1%) were positive for HBsAg which were statistically significant with (COR 2.9 and 95% CI 1.4-6.). Of those who were Child-Pugh Class A (113) were positive for HBsAg 103 (52.8) (COR, 5.5; 95% CI, 2.2–14; P-Value 0.0001) and compensated patient where (COR, 8; 95% CI, 3.5–19; P-Value 0.0001) for which both are statically significant. Risk factors associated with HBV among chronic liver disease the following were significantly associated with hospital admission (COR, 53.4; 95% CI, 1.5–8; P-Value 0.002) and blood transfusion (COR, 0.22; 95% CI, 0.1–0.5; P-Value 0.0001). Conclusions: The present study has shown that HBV (79.5%) was highly prevalent among patients with chronic liver disease. Screening all possible close contacts (relatives) of patients with HBV and giving immunization to this group and if possible giving public immunization of HBV is recommended to halt HBV infection. Most patients in this study group are compensated 57.4% and Child Class A 59.5% which gives time to implement treatment to decrease disease progression to the worsen. and this study will give insight into availing appropriate medication for treatment

VL  - 13
IS  - 1
ER  -

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